Where possible, make sure to destroy or counter that source of hexproof, as it usually wont have hexproof itself
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The strategy is a simple one, maintain a constant field presence bolstered by (albeit fairly weak) secondary effects
Then there's a point in the game when your opponent eyes your creatures for removal, you'll appreciate some fresh respect for 1-mana spells that protect your creatures
The alternate commander, The Lord of Pain, pings enemies for damage whenever a player casts their first spell, which is not only an excellent tool to make your opponents kill each other, but a decent deterrent to not remove them quickly
I feel as though the Mewtwo boosters will contain some of the better cards overall, but your first pick should be based on which of the above cards appeal to you the most